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Application of explicite criteria of medications potentially inappropriate in the old age in the evaluation of quality of prescribing (III.)
Grešáková, Silvia ; Fialová, Daniela (advisor) ; Zimčíková, Eva (referee)
Introduction: Propotion of older people is rapidly increasing in the world population. Elderly represents a specific, heterogenous population which is because of many reasons more vulnerable to some adverse drug events. Many explicit criteria of potentially inappropriate medication used in the elderly have been developed in order to improve the quality and safety of geriatric pharmacotherapy. These criteria represent basic tools, defining fundamental prescribing rules for the evaluation of appropriate choice and dosing of medications in the old age and for the evaluation of potentially inappropriate prescriptions in older patiens. The aim of the diploma thesis was to compare advantages and disadvantages of explicit criteria published until the end of 2015 year and to summarizea list of allpotentially inappropriate medications in the elderly (regardless of diagnoses and concomitantly used medications), applicable in the epidemiological studies of the EU COST Action 1402project and in subsequent studies. Methods: Using systematic literature search in PubMed dataset, conducted in the period 04/2015 - 12/2015, all explicit and explicit- implicit criteria (published in the foreign peer- reviewed scientific journals bythe end of year 2015 and validated by expert panels) have been identified. Information...
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Evaluation of potentially inappropriate drugs and drug procedures in the old age (I.)
Krivošová, Michaela ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
Introduction: Proportion of the population over the age of 65 is continuously increasing in the European Union, and therefore, the number of polymorbid patients with polypharmacy, limited functional capacities and syndrome of geriatric frailty is rising every year as well. In order to support the quality of geriatric prescribing and to lower possible adverse drug events, explicit criteria for potentially inappropriate drugs and drug procedures for elderly have been created. The aim of the diploma thesis was to evaluate how many potentially inappropriate medications (PIMs) for elderly out of 22 explicit criteria were registered in 6 countries (Czech Republic, Hungary, Portugal, Serbia, Spain and Turkey) participating at the 1st phase of the EU COST Action IS1402 initiative and which criterion or what group of regional criteria (European, American, Asian) would be the most specific and most suitable in individual countries for prospective international study following the quality of PIM prescribing. Methods: Of 22 explicit criteria of drugs/drug procedures potentially inappropriate in the old age, validated and published in peer-review journals and journals with the impact factor by 2015 year, a list of all until now known 345 PIMs was created (disregarding the dosage scheme, interval of use or...
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Evaluation of potentially inappropriate drugs and drug procedures in the old age (I.)
Krivošová, Michaela ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
Introduction: Proportion of the population over the age of 65 is continuously increasing in the European Union, and therefore, the number of polymorbid patients with polypharmacy, limited functional capacities and syndrome of geriatric frailty is rising every year as well. In order to support the quality of geriatric prescribing and to lower possible adverse drug events, explicit criteria for potentially inappropriate drugs and drug procedures for elderly have been created. The aim of the diploma thesis was to evaluate how many potentially inappropriate medications (PIMs) for elderly out of 22 explicit criteria were registered in 6 countries (Czech Republic, Hungary, Portugal, Serbia, Spain and Turkey) participating at the 1st phase of the EU COST Action IS1402 initiative and which criterion or what group of regional criteria (European, American, Asian) would be the most specific and most suitable in individual countries for prospective international study following the quality of PIM prescribing. Methods: Of 22 explicit criteria of drugs/drug procedures potentially inappropriate in the old age, validated and published in peer-review journals and journals with the impact factor by 2015 year, a list of all until now known 345 PIMs was created (disregarding the dosage scheme, interval of use or...
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Evaluation of potentially inappropriate drugs and drug procedures in the old age (III.)
Pohořalá, Veronika ; Fialová, Daniela (advisor) ; Zimčíková, Eva (referee)
INTRODUCTION: The percentage of seniors in the population is increasing worldwide and Europe is not an exception in this case. Geriatric patients create a very specific group of patients in which the risk of drug-related problems is increased due to many reasons. Explicit criteria of potentially inappropriate medications/drug procedures (PIMs) in the aged belong to instruments helping with the evaluation of the quality of drug prescribing to older patients and have been developed in the past decades with the aim to increase the quality of geriatric pharmacotherapy and to minimize the quantity and severity of adverse drug reactions. The aim of this thesis is to evaluate the registration rates and OTC availability of pharmaceuticals from the PIMs list created for the purposes of EU COST Action IS1402 initiative (2015-2018) in 5 countries - Czech Republic, Estonia, Croatia, Poland and Slovakia. METHODOLOGY: Based on the thesis by S. Grešáková, MS, a list of 487 potentially inappropriate medicines/drug procedures in the aged has been created and subsequently also the record table stating the individual PIMs and other requested characteristics that was later filled by research teams of participating countries in the period from December 2016 to April 2017. In each country the following attributes were monitored:...
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Evaluation of potentially inappropriate drugs and drug procedures in the old age (I.)
Krivošová, Michaela ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
Introduction: Proportion of the population over the age of 65 is continuously increasing in the European Union, and therefore, the number of polymorbid patients with polypharmacy, limited functional capacities and syndrome of geriatric frailty is rising every year as well. In order to support the quality of geriatric prescribing and to lower possible adverse drug events, explicit criteria for potentially inappropriate drugs and drug procedures for elderly have been created. The aim of the diploma thesis was to evaluate how many potentially inappropriate medications (PIMs) for elderly out of 22 explicit criteria were registered in 6 countries (Czech Republic, Hungary, Portugal, Serbia, Spain and Turkey) participating at the 1st phase of the EU COST Action IS1402 initiative and which criterion or what group of regional criteria (European, American, Asian) would be the most specific and most suitable in individual countries for prospective international study following the quality of PIM prescribing. Methods: Of 22 explicit criteria of drugs/drug procedures potentially inappropriate in the old age, validated and published in peer-review journals and journals with the impact factor by 2015 year, a list of all until now known 345 PIMs was created (disregarding the dosage scheme, interval of use or...
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Evaluation of potentially inappropriate drugs and drug procedures in the old age (II.)
Vyšínová, Tereza ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
INTRODUCTION: The issue of care for older patients has recently been discussed more and more frequently. The proportion of older adults in the population has been raising exponentially, especially in the last few decades, so the expectations concerning the extent and quality of geriatric care increases as well. In order to improve the quality of pharmacotherapy in the old age, many tools have been published in the last 25 years aimed at support of physicians in better care for older adults, enabling selection of safer pharmacotherapeutic startegies that respect specific pharmacological, physiological and homeostatic changes in the old age. Consequently, multiple explicit criteria of potentially inappropriate drugs and drug procedures (PIMs) have been published to help clinicians to distinguish pharmacotherapeutic strategies of choice for geriatric patients and oppositely to identify drugs, indications and dosing schedules potentially inappropriate in seniors. The aim of this diploma thesis was to evaluate in the pilot round the registration rates and other issues related to availability of all known PIMs in countries participating in the EU COST Action IS1402 study. METHODOLOGY: Based on diploma thesis of S. Grešáková, MS ("Application of explicite criteria of medications potentially inappropriate...
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Application of explicite criteria of medications potentially inappropriate in the old age in the evaluation of quality of prescribing (III.)
Grešáková, Silvia ; Fialová, Daniela (advisor) ; Zimčíková, Eva (referee)
Introduction: Propotion of older people is rapidly increasing in the world population. Elderly represents a specific, heterogenous population which is because of many reasons more vulnerable to some adverse drug events. Many explicit criteria of potentially inappropriate medication used in the elderly have been developed in order to improve the quality and safety of geriatric pharmacotherapy. These criteria represent basic tools, defining fundamental prescribing rules for the evaluation of appropriate choice and dosing of medications in the old age and for the evaluation of potentially inappropriate prescriptions in older patiens. The aim of the diploma thesis was to compare advantages and disadvantages of explicit criteria published until the end of 2015 year and to summarizea list of allpotentially inappropriate medications in the elderly (regardless of diagnoses and concomitantly used medications), applicable in the epidemiological studies of the EU COST Action 1402project and in subsequent studies. Methods: Using systematic literature search in PubMed dataset, conducted in the period 04/2015 - 12/2015, all explicit and explicit- implicit criteria (published in the foreign peer- reviewed scientific journals bythe end of year 2015 and validated by expert panels) have been identified. Information...
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